ORGANOPHOSPHORUS POISONING THESIS

The duration of mechanical ventilation increased with the increase in lag time. Once atropinised maintenance dose of mg was given every hourly. However, the confidentiality of the patients was maintained by not mentioning the name, registration number, and the date of birth of the patient. The duration of mechanical ventilation increased with the increase in lag time. The differences between these 2 groups were statistically significant. It is estimated by the World Health Organization that approximately , persons die of organophosphorus pesticide poisoning per year. A review of the evidence in India; pp.

In the study by Aziza et al. Chi square test, Pearson correlation test, and multivariate binary logistic regression analysis was used. The diagnosis was not supported by measuring plasma or red blood cell anticholinesterase levels since these are not measured in our hospital. National Center for Biotechnology Information , U. OP compounds are used worldwide in agriculture as well as in household gardens.

organophosphorus poisoning thesis

The financial impact of such therapy, particularly in rural India has been raised as an issue in absence of definite beneficial effect of oximes in OP poisoning. Organophosphorus insecticides OP are probably the most widely used pesticides in the world.

National Poison Information Centre (24×7)

OP insecticides inhibit both cholinesterase and pseudocholinesterase activities, as they are irreversible cholinesterase inhibitors. The high mortality in patients ventilated for days is most probably due to the severity of poisoning. These patients probably organophosphoorus increased lag time or reported late to the A and E resulting in severe degree of poisoning leading to severe respiratory failure.

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J Assoc Physicians India.

Severity of poisoning, lag time and duration of mechanical ventilation. It is of great concern since it affects the most productive age group of the society.

There was a positive and linear correlation between lag time and mechanical ventilation. Acute organopshophorous poisoning in Srilanka.

MSc dissertation Publication date: Patients in the control group received routine emergency treatment, including gastrolavage, catharsis, rehydration, maintenance of water-electrolyte balance, and anti-infection treatment.

The average dose of PAM required per patient was It is of great concern since it affects the most productive age group of the society.

OP compounds are used worldwide in agriculture as well as in household gardens. N Engl J Med. Anticoagulation was conducted with sodium heparin.

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Thirty-four patients received hemodialysis and hemoperfusion for times, and 25 patients had complications. The duration of mechanical ventilation in our patients was 4. Lag time was less than 6 hrs in 13 patients and all of them survived.

Administration of PAM and atropine was continued till the target end point was reached. In our study, the incidence of suicidal poisoning is The treatment for OP poisoning involves a combination of muscarinic antagonists, organoposphorus as atropine ATR ; oximes for reactivating the ChEs, mainly represented by the pralidoxime 2-PAM and benzodiazepines, generally diazepam, for treatment of occasional seizures.

The dose of atropine and injection interval were adjusted according to changes in the patient’s condition, and these were adjusted every 5 to 20 minutes, to reach the atropinization organophosphors in the shortest possible time and to maintain atropinization. Multivariate binary logistic regression analysis was done with death as the dependent variable and age, lag time to PAM therapy, severity of poisoning and duration of ventilation as the covariates.

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Intermediate syndrome in organophosphorus poisoning: Organophosphorus poisoning in Kashmir Valley.

organophosphorus poisoning thesis

The recorded time interval between OP poisoning and starting of Organolhosphorus lag time was significantly higher in those who died. World Health Organisation; These patients probably had increased lag time or reported late to the A and E resulting in severe degree of poisoning leading to organiphosphorus respiratory failure. The mortality is very high since the victims are predominantly from rural India where poisoning is very severe due to delay in the access to medical management.

These patients were divided into 2 groups: All the patients were then shifted to the ICU for further management. Poisoning due to organophosphate insecticides. From hospitalization on, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, length of hospital stay, mortality, poisoning rebound rate, and the success rate of rescue were recorded in detail.

organophosphorus poisoning thesis

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